Botox Treatment for Migraine

BOTOX® (onabotulinumtoxinA) is a prescription medicine that is injected into muscles and indicated to prevent chronic headaches. Botox® has been approved for treating headaches that are present more than 15 days per month. It is used to prevent headaches in adults with chronic migraine, who have 15 or more days each month with headache lasting 4 or more hours each day, in people 18 or older.

Also referred to as Botulinum toxin, it is a neurotoxin produced by clostridium botulinum, the bacteria that thrive in conditions without oxygen (ie: anaerbic state), and may produce severe food poisoning called Botulism. This is the toxin that paralyzes nerves by blocking the release of a substance called acetylcholine which blocks nerve signals to muscles and prevents them from contracting thereby causing relaxation. The toxin is a poison only if ingested with a spoiled food.

However, for medicinal use, Botox® is injected directly into muscles rather than absorbed from the stomach. The injected dose is a fraction of that which causes botulism. No single case of Botulism related to Botox has ever been reported.

Botox® is well known for its use in treatment of wrinkles. It has approval for use in treating facial tics and spasms, dystonia and other forms of spasticity in cerebral palsy for example. Its tolerability and safety record for these uses are excellent.

The discovery of Botox® for treatment of migraine was quite by accident. Several patients who were using Botox® for injection of wrinkles and also happened to have migraine. They reported improvement in headaches following injection into their brow and forehead muscles.

The mechanism of action involved in the alleviation of headache is not entirely clear. One possibility is that Botox® may decrease muscle contraction that may act as a trigger to migraine. Another theory is that Botox® may act on the brain chemicals called neurotransmitters and mediators that trigger pain and migraine.

Careful trials studying migraine and chronic headache patients continue to examine the efficacy of Botox®. Several clinical trials including a large placebo controlled study, have been completed and demonstrated effectiveness of this therapy. Botox® is approved by FDA and Health Canada for treatment and prevention of chronic migraine. Health Canada approved Botox® for the treatment of chronic migraines in 2011. More studies exploring Botox® benefits in migraine and other types of headaches, are ongoing.

The average dose is 100-200 units. The onset of action is usually within the first 2-3 weeks of injection. However, patients may require a set of 2-3 injections before a maximum benefit is seen. Injections are spaced at 12 week intervals.

Safety is always a concern. However, Botox® record since 1989 is excellent. There is no significant absorption as there is with oral medication; therefore no systemic side-effects are seen. Occasionally, patients may experience short-lived symptoms resembling a mild flu. Drooping eyelids may occur with improper injection techniques, but this is transient. Botox® can be considered in patients when other migraine treatments fail or are contradicted. BOTOX is covered by the ODB (Ontario Drug Benefits) program.

At present the use of Botox® is restricted to a few specialized headache centres, but as time goes on more trained specialists will be available. In all cases, however, patients should receive assurance that the person injecting Botox® has received appropriate training, both in the diagnosis and management of chronic migraine, and in administration of the drug itself.

On the Help for Headaches website there is a newly updated Find-a-Headache-Doctor program, that covers all Canadian provinces. If you are searching for a Headache Neurologist, this program can help you find one. The online program is on the charity website on the lower-right bottom of the homepage. A direct link to this Ontario program can be found at or if you suspect Chronic Migraine visit There is also a Doctor Locator at the my chronic migraine website found here.

by Brent Lucas BA, Headache Researcher, Director, Help for Headaches, London, Ontario, Canada

Updated October 2015 medically by: Dr. Michael Gofeld, MD. DEAA, FIPP Associate Professor, University of Toronto, Staff Physician, Department of Anesthesia St. Michael’s & Women’s College Hospitals, Toronto, Ontario, Canada

Click a province on the map above
or the list below:
   British Columbia

New Brunswick 
   Nova Scotia 
Prince Edward Island 
Newfoundland / Labrador
Northwest Territories 
Yukon Territories

The book Chronic Daily Headache features
an article reviewed by a Headache Neurologist
entitled "Why Some Headache Patients do
not Improve"!